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University Imaging Centers - Where the University sees the future

Journal Articles

A rocky road for the maturation of embryo-editing methods

Nature Methods - 21 January 2019 - 12:00am

A rocky road for the maturation of embryo-editing methods

A rocky road for the maturation of embryo-editing methods, Published online: 21 January 2019; doi:10.1038/s41592-018-0307-5

A rocky road for the maturation of embryo-editing methods
Categories: Journal Articles

A genetically encoded near-infrared fluorescent calcium ion indicator

Nature Methods - 21 January 2019 - 12:00am

A genetically encoded near-infrared fluorescent calcium ion indicator

A genetically encoded near-infrared fluorescent calcium ion indicator, Published online: 21 January 2019; doi:10.1038/s41592-018-0294-6

NIR-GECO1, the first near-infrared genetically encoded calcium ion (Ca2+) indicator, enables improved Ca2+ imaging in conjunction with blue-light-activated optogenetic tools and multiplexed imaging in cell cultures and tissue slices.
Categories: Journal Articles

A discriminative learning approach to differential expression analysis for single-cell RNA-seq

Nature Methods - 21 January 2019 - 12:00am

A discriminative learning approach to differential expression analysis for single-cell RNA-seq

A discriminative learning approach to differential expression analysis for single-cell RNA-seq, Published online: 21 January 2019; doi:10.1038/s41592-018-0303-9

Logistic regression predicts differential gene expression and transcript usage.
Categories: Journal Articles

An online resource for GPCR structure determination and analysis

Nature Methods - 21 January 2019 - 12:00am

An online resource for GPCR structure determination and analysis

An online resource for GPCR structure determination and analysis, Published online: 21 January 2019; doi:10.1038/s41592-018-0302-x

An interactive online resource integrated in the GPCRdb hub presents tools to design GPCR constructs and determine appropriate experimental conditions for structural studies by crystallography and cryo-EM.
Categories: Journal Articles

Inferring bacterial recombination rates from large-scale sequencing datasets

Nature Methods - 21 January 2019 - 12:00am

Inferring bacterial recombination rates from large-scale sequencing datasets

Inferring bacterial recombination rates from large-scale sequencing datasets, Published online: 21 January 2019; doi:10.1038/s41592-018-0293-7

Fitting the correlation profile of synonymous substitutions within a metagenomics sample can allow one to infer the rate of recombination, gene pool diversity, the fraction of the genome covered by recombination and the relative age of the sample.
Categories: Journal Articles

A robust and versatile platform for image scanning microscopy enabling super-resolution FLIM

Nature Methods - 14 January 2019 - 12:00am

A robust and versatile platform for image scanning microscopy enabling super-resolution FLIM

A robust and versatile platform for image scanning microscopy enabling super-resolution FLIM, Published online: 14 January 2019; doi:10.1038/s41592-018-0291-9

A single-photon detector array enables robust and versatile image scanning microscopy (ISM) on any confocal microscope. This implementation makes super-resolution FLIM possible and eases a transition from confocal microscopy to ISM.
Categories: Journal Articles

Metagenomic engineering of the mammalian gut microbiome in situ

Nature Methods - 14 January 2019 - 12:00am

Metagenomic engineering of the mammalian gut microbiome in situ

Metagenomic engineering of the mammalian gut microbiome in situ, Published online: 14 January 2019; doi:10.1038/s41592-018-0301-y

MAGIC introduces conjugative plasmids into complex microbial communities in situ, enabling genetic modifications in gut microbiota.
Categories: Journal Articles

idtracker.ai: tracking all individuals in small or large collectives of unmarked animals

Nature Methods - 14 January 2019 - 12:00am

idtracker.ai: tracking all individuals in small or large collectives of unmarked animals

idtracker.ai: tracking all individuals in small or large collectives of unmarked animals, Published online: 14 January 2019; doi:10.1038/s41592-018-0295-5

The idtracker.ai software tracks freely moving animals in large groups of up to 100 individuals. The tool is versatile and has been applied to groups of fruit flies, zebrafish, medaka, ants and mice.
Categories: Journal Articles

Author Correction: A pH-correctable, DNA-based fluorescent reporter for organellar calcium

Nature Methods - 14 January 2019 - 12:00am

Author Correction: A pH-correctable, DNA-based fluorescent reporter for organellar calcium

Author Correction: A pH-correctable, DNA-based fluorescent reporter for organellar calcium, Published online: 14 January 2019; doi:10.1038/s41592-019-0309-y

Author Correction: A pH-correctable, DNA-based fluorescent reporter for organellar calcium
Categories: Journal Articles

Gonzalo G. de Polavieja

Nature Methods - 14 January 2019 - 12:00am

Gonzalo G. de Polavieja

Gonzalo G. de Polavieja, Published online: 14 January 2019; doi:10.1038/s41592-018-0306-6

How AI can help track animals and why breakfast powers collaboration.
Categories: Journal Articles

Author Correction: Genome-wide SWAp-Tag yeast libraries for proteome exploration

Nature Methods - 2 January 2019 - 12:00am

Author Correction: Genome-wide SWAp-Tag yeast libraries for proteome exploration

Author Correction: Genome-wide SWAp-Tag yeast libraries for proteome exploration, Published online: 02 January 2019; doi:10.1038/s41592-018-0297-3

Author Correction: Genome-wide SWAp-Tag yeast libraries for proteome exploration
Categories: Journal Articles

Publisher Correction: Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR

Nature Methods - 2 January 2019 - 12:00am

Publisher Correction: Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR

Publisher Correction: Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR, Published online: 02 January 2019; doi:10.1038/s41592-018-0300-z

Publisher Correction: Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR
Categories: Journal Articles

Author Correction: Faster, sharper, and deeper: structured illumination microscopy for biological imaging

Nature Methods - 29 December 2018 - 12:00am

Author Correction: Faster, sharper, and deeper: structured illumination microscopy for biological imaging

Author Correction: Faster, sharper, and deeper: structured illumination microscopy for biological imaging, Published online: 29 December 2018; doi:10.1038/s41592-018-0296-4

Author Correction: Faster, sharper, and deeper: structured illumination microscopy for biological imaging
Categories: Journal Articles

Publisher Correction: Sequence meets space

Nature Methods - 21 December 2018 - 12:00am

Publisher Correction: Sequence meets space

Publisher Correction: Sequence meets space, Published online: 21 December 2018; doi:10.1038/s41592-018-0299-1

Publisher Correction: Sequence meets space
Categories: Journal Articles

Author Correction: Comparing phenotypic variation between inbred and outbred mice

Nature Methods - 21 December 2018 - 12:00am

Author Correction: Comparing phenotypic variation between inbred and outbred mice

Author Correction: Comparing phenotypic variation between inbred and outbred mice, Published online: 21 December 2018; doi:10.1038/s41592-018-0298-2

Author Correction: Comparing phenotypic variation between inbred and outbred mice
Categories: Journal Articles

Detecting protein glycosylation

Nature Methods - 20 December 2018 - 12:00am

Detecting protein glycosylation

Detecting protein glycosylation, Published online: 20 December 2018; doi:10.1038/s41592-018-0284-8

Detecting protein glycosylation
Categories: Journal Articles

Reliability of human cortical organoid generation

Nature Methods - 20 December 2018 - 12:00am

Reliability of human cortical organoid generation

Reliability of human cortical organoid generation, Published online: 20 December 2018; doi:10.1038/s41592-018-0255-0

A protocol adapted to xeno- and feeder-free conditions is shown to generate reliable and consistent cortical brain organoids across differentiations and source stem cell lines, making it suitable for disease modeling and other applications.
Categories: Journal Articles

Membrane protein complexes exposed

Nature Methods - 20 December 2018 - 12:00am

Membrane protein complexes exposed

Membrane protein complexes exposed, Published online: 20 December 2018; doi:10.1038/s41592-018-0290-x

A vesicle-based mass spectrometry method enables the analysis of protein complexes in native membranes.
Categories: Journal Articles

Sensing neurotransmitters

Nature Methods - 20 December 2018 - 12:00am

Sensing neurotransmitters

Sensing neurotransmitters, Published online: 20 December 2018; doi:10.1038/s41592-018-0268-8

Genetically encoded neurotransmitter sensors will shed light on neuronal communication.
Categories: Journal Articles

A tiny macroscope to look into complex behavior

Nature Methods - 20 December 2018 - 12:00am

A tiny macroscope to look into complex behavior

A tiny macroscope to look into complex behavior, Published online: 20 December 2018; doi:10.1038/s41592-018-0287-5

A macroscope mounted on the head of a freely moving transgenic rat can help shine light on complex behaviors.
Categories: Journal Articles

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