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Nature Methods

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Nature Methods is a science methodology journal publishing laboratory techniques and methods papers in the life sciences and areas of chemistry relevant to the life sciences.
Updated: 7 hours 42 min ago

Uncovering axes of variation among single-cell cancer specimens

13 January 2020 - 12:00am

Nature Methods, Published online: 13 January 2020; doi:10.1038/s41592-019-0689-z

Phenotypic earth mover’s distance (PhEMD) facilitates the comparison of single-cell experimental conditions, each of which is a high-dimensional dataset, and identifies axes of variation among multicellular biospecimens.
Categories: Journal Articles

MINFLUX nanoscopy delivers 3D multicolor nanometer resolution in cells

13 January 2020 - 12:00am

Nature Methods, Published online: 13 January 2020; doi:10.1038/s41592-019-0688-0

Advances in MINFLUX nanoscopy enable multicolor imaging over large fields of view, bringing true nanometer-scale fluorescence imaging to labeled structures in fixed and living cells.
Categories: Journal Articles

Optically measuring barcodes

6 January 2020 - 12:00am

Nature Methods, Published online: 06 January 2020; doi:10.1038/s41592-019-0716-0

Optically measuring barcodes
Categories: Journal Articles

Structures in situ

6 January 2020 - 12:00am

Nature Methods, Published online: 06 January 2020; doi:10.1038/s41592-019-0704-4

Structures in situ
Categories: Journal Articles

Built by association

6 January 2020 - 12:00am

Nature Methods, Published online: 06 January 2020; doi:10.1038/s41592-019-0723-1

A protein co-regulation database facilitates proteome-wide functional annotations.
Categories: Journal Articles

Informatics for genomics

6 January 2020 - 12:00am

Nature Methods, Published online: 06 January 2020; doi:10.1038/s41592-019-0709-z

Informatics for genomics
Categories: Journal Articles

Single-cell multimodal omics: the power of many

6 January 2020 - 12:00am

Nature Methods, Published online: 06 January 2020; doi:10.1038/s41592-019-0691-5

Advances in single-cell genomics technologies have enabled investigation of the gene regulation programs of multicellular organisms at unprecedented resolution and scale. Development of single-cell multimodal omics tools is another major step toward understanding the inner workings of biological systems.
Categories: Journal Articles

Publisher Correction: Directed evolution improves the catalytic efficiency of TEV protease

6 January 2020 - 12:00am

Nature Methods, Published online: 06 January 2020; doi:10.1038/s41592-019-0729-8

Publisher Correction: Directed evolution improves the catalytic efficiency of TEV protease
Categories: Journal Articles

Putting on the squeeze

6 January 2020 - 12:00am

Nature Methods, Published online: 06 January 2020; doi:10.1038/s41592-019-0711-5

Putting on the squeeze
Categories: Journal Articles

Biophysical prediction of protein–peptide interactions and signaling networks using machine learning

6 January 2020 - 12:00am

Nature Methods, Published online: 06 January 2020; doi:10.1038/s41592-019-0687-1

Protein–peptide interactions that underpin cell signaling are accurately predicted by wedding the strengths of machine learning with the interpretability of biophysical theory, facilitating detailed mechanistic analyses at the proteome scale.
Categories: Journal Articles

Publisher Correction: The Author File: Sündüz Keleş

27 December 2019 - 12:00am

Nature Methods, Published online: 27 December 2019; doi:10.1038/s41592-019-0725-z

Publisher Correction: The Author File: Sündüz Keleş
Categories: Journal Articles

Boost that metabolomic confidence

20 December 2019 - 12:00am

Nature Methods, Published online: 20 December 2019; doi:10.1038/s41592-019-0694-2

Change is a constant in the burgeoning field of metabolomics. That includes data analysis tools and repositories.
Categories: Journal Articles

Publisher Correction: Orchestrating single-cell analysis with Bioconductor

11 December 2019 - 12:00am

Nature Methods, Published online: 11 December 2019; doi:10.1038/s41592-019-0700-8

Publisher Correction: Orchestrating single-cell analysis with Bioconductor
Categories: Journal Articles

Publisher Correction: Analysis of the Human Protein Atlas Image Classification competition

10 December 2019 - 12:00am

Nature Methods, Published online: 10 December 2019; doi:10.1038/s41592-019-0699-x

Publisher Correction: Analysis of the Human Protein Atlas Image Classification competition
Categories: Journal Articles

Directed evolution improves the catalytic efficiency of TEV protease

9 December 2019 - 12:00am

Nature Methods, Published online: 09 December 2019; doi:10.1038/s41592-019-0665-7

An optogenetic strategy enables selection of proteases with improved catalytic rates. The developed TEV protease variants are well suited for biotechnology applications, including FLARE assays with substantially improved temporal resolution.
Categories: Journal Articles

Deciphering interaction fingerprints from protein molecular surfaces using geometric deep learning

9 December 2019 - 12:00am

Nature Methods, Published online: 09 December 2019; doi:10.1038/s41592-019-0666-6

MaSIF, a deep learning-based method, finds common patterns of chemical and geometric features on biomolecular surfaces for predicting protein–ligand and protein–protein interactions.
Categories: Journal Articles

Fast and accurate long-read assembly with wtdbg2

9 December 2019 - 12:00am

Nature Methods, Published online: 09 December 2019; doi:10.1038/s41592-019-0669-3

Wtdbg2 assembles genomes with comparable contiguity and accuracy to existing tools using long-read sequencing data, and is several times faster, especially for large genomes.
Categories: Journal Articles

Author Correction: Nanopore native RNA sequencing of a human poly(A) transcriptome

9 December 2019 - 12:00am

Nature Methods, Published online: 09 December 2019; doi:10.1038/s41592-019-0697-z

Author Correction: Nanopore native RNA sequencing of a human poly(A) transcriptome
Categories: Journal Articles

Localization microscopy at doubled precision with patterned illumination

9 December 2019 - 12:00am

Nature Methods, Published online: 09 December 2019; doi:10.1038/s41592-019-0657-7

SIMFLUX combines elements of MINFLUX with structured illumination to double localization precision and improve resolution in localization microscopy. The approach was demonstrated on DNA origami and on cellular microtubules.
Categories: Journal Articles

Publisher Correction: Gas cluster ion beam SEM for imaging of large tissue samples with 10 nm isotropic resolution

4 December 2019 - 12:00am

Nature Methods, Published online: 04 December 2019; doi:10.1038/s41592-019-0695-1

Publisher Correction: Gas cluster ion beam SEM for imaging of large tissue samples with 10 nm isotropic resolution
Categories: Journal Articles

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