University of Minnesota
University Imaging Center
http://uic.umn.edu/
612.624.7938
University Imaging Centers - Where the University sees the future

Equipment

Equipment Description Location
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Bruker Xtreme Optical and X-ray small animal imaging system

ATTENTION: THIS SYSTEM IS LOCATED IN THE CANCER CARDIOVASCULAR RESEARCH BUILDING, RM 1-250E. PLEASE CONTACT UIC STAFF FOR ACCESS AND TRAINING BEFORE USING.

The Xtreme system combines high-sensitivity optical molecular imaging (Biolumenescence and Fluorescence) along with high-resolution digital x-ray to deliver precise anatomical localization of molecular and cellular biomarkers in vivo.  Software automation simplifies complex multimodal imaging protocols for small animal imaging. The system includes animal handling features such as a heated sample shelf, a gas anesthesia system and MARS 360 degree animal rotation system (https://www.youtube.com/watch?v=V49qHYAqWsY). 

Bone denstiy measurements are possible: https://www.youtube.com/watch?v=FPfd6_5rung

System purchased with the generous support of the OVPR, CBS and AHC/Medical School through an I3 award. 

•Please do not use this equipment without contacting UIC staff for training and approval. Request training here:

  http://uic.umn.edu/node/add/training-request

•Please return all animals to the Catch Room (rm 1-370F) following imaging.  Contact RAR staff for housing information.

•Please contact UIC staff with any questions.

  http://uic.umn.edu/

 

Room 1-250E CCRB

IVIS Spectrum In Vivo Imaging System

The IVIS Spectrum is the most versatile and advanced in vivo imaging system available on the market today. An optimized set of high efficiency filters and spectral un-mixing algorithms lets you take full advantage of bioluminescent and fluorescent reporters across the blue to near infrared wavelength region. It also offers single-view 3D tomography for both fluorescent and bioluminescent reporters that can be analyzed in an anatomical context using our Digital Mouse Atlas.

For advanced fluorescence imaging, the IVIS Spectrum has the capability to use either trans-illumination (from the bottom) or epi-illumination (from the top) to illuminate in vivo fluorescent sources. 3D diffuse fluorescence tomography can be performed to determine source localization and concentration using the combination of structured light and trans illumination fluorescent images. The instrument is equipped with 10 narrow band excitation filters (30nm bandwidth) and 18 narrow band emission filters (20nm bandwidth) that assist in significantly reducing autofluorescence by the spectral scanning of filters and the use of spectral unmixing algorithms. In addition, the spectral unmixing tools allow the researcher to separate signals from multiple fluorescent reporters within the same animal.

Additional details, specifications and vendor protocols can be found here: http://www.perkinelmer.com/Catalog/Product/ID/IVISSPE

 

Room 1-166A Jackson Hall

Maestro In-Vivo Imaging System

Maestro provides users with a patented method of removing autofluorescence emitted from images of plant and animal tissues to reveal otherwise hard-to-detect labeled targets of interest. The dramatic improvement in signal-to-noise can increase sensitivity up to several hundred-fold, enabling much smaller or fainter signals from biological targets to be detected earlier and accurately measured. The increased sensitivity over standard imaging techniques provided by Maestro’s high-quality spectral imaging technology enable experiments and models which simply cannot be performed on any other system.

Room 37A Snyder Hall

Siemens Inveon µPET/CT

 

February 21, 2019.

Dear Users of the Siemens Inveon µPET/CT,

As a user of the µPET/CT in the University Imaging Centers (UIC), I need to alert you to our decision to stop offering µPET/CT services. The µPET/CT will be decommissioned May 31, 2019.

The average revenue from last fiscal year was ~$12,000 and a similar level of revenues is projected for FY19. The yearly expenses are $100,000.  Over half of the expense ($55,000) is for the annual service agreement, with the remaining expenses for labor, supplies and software fees.  Since transferring the µPET/CT under UIC’s management in 2016, the Medical School and UIC have been heavily subsidizing the costs of operating the µPET/CT.

The decision to remove the µPET/CT has been a difficult one. However, the UIC cannot continue to sustain an $85,000 annual operating deficits on this instrument. Hopefully, this notice will provide the time needed to make other arrangements for your future µPET/CT imaging needs. Discussions for extending Inveon PET/CT operations would need to come with guaranteed user fees. I suggest you consult with Mark Sanders, Director of the UIC, on other options for small and large animal imaging services in Minnesota. 

 

Sincerely,

Timothy J. Ebner, M.D., Ph.D.

Professor and Head

Department of Neuroscience

 

Getting Started:

To schedule an initial PET/CT imaging consultation please contact:

Instrument Overview:

A Siemens Inveon preclinical microPET/CT now augments the center's extensive MR capabilities. microPET/CT is a molecular level functional imaging modality that provides valuable insight into biochemical, physiological, pathological and/or pharmacological processes in vivo. The microPET/CT can be used in a number of ways. This information can be obtained via a non-invasive, in vivo imaging process that allows both serial and longitudinal studies to be performed and in a continuous and comparative way. Other areas can be assessed such as novel drug delivery, effects of intervention, and progression and outcome of a particular therapy. Examples of biomedical applications specific to the microPET/CT using FDG:

  • Myocardial viability.
  • Tumor glucose metabolism.
  • Gastrointestinal graft-versus-host disease (GVHD).
  • Neurotransmitter function in vivo over time, e.g. Huntington's, Parkinson's, Alzheimer's disease.
  • Time-activity profiles reflecting tracer delivery, binding and washout, i.e., pharmokinetics.
  • Development of new radiopharmaceuticals for use in diagnostic imaging and new molecular imaging assays.
  • Acquisition of sequential PET and CT data without repositioning.
Room 1-260F CCRB

Vevo 2100 System (CCRB)

The first high-frequency, high-resolution digital imaging platform with linear array technology and color doppler mode.

Instrument details can be found here: http://www.visualsonics.com/vevo2100#

Room 1-260D CCRB

Vevo 2100 System (JH)

The first high-frequency, high-resolution digital imaging platform with linear array technology and color doppler mode.
Detailed specifications can be found here:  http://www.visualsonics.com/vevo2100

Room 1-161 Jackson Hall

Xenogen IVIS 100 in vivo Imaging System

ATTENTION: THIS SYSTEM IS LOCATED IN THE CANCER CARDIOVASCULAR RESEARCH BUILDING, RM 1-260C.

The IVIS 100 Imaging System is a highly sensitive and large field of view imaging system that offers users the flexibility to image bioluminescent reporters both in vivo and in vitro. It relies on patented optical imaging technologies to facilitate non-invasive longitudinal monitoring of disease progression, cell trafficking and gene expression patterns in living animals.

•Please do not use this equipment without contacting UIC staff for training and approval. Request training here:

  http://uic.umn.edu/node/add/training-request

•Please accurately reserve and record all usage on the appropriate reservation calendar. Reserve and record usage here:

  http://uic.umn.edu/content/uic-reservation-system

•Please return all animals to the Catch Room (rm 1-370F) following imaging.  Contact RAR staff for housing information.

•Please contact UIC staff with any questions.

  http://uic.umn.edu/

 

Room 1-260C CCRB